Pregascreen Quadruple Marker Reflex Test

Reasons for Undergoing the Quad Marker Test

The Quadruple Marker Test, also known as the quad screen or Quadruple Test, is a crucial prenatal screening tool that expectant mothers undergo for various reasons: 

• Assessing the risk of chromosomal abnormalities such as Down syndrome (trisomy 21) and Edwards syndrome (trisomy 18) in the foetus.
• Screening for open neural tube defects, including spina bifida and anencephaly. 
• Identifying multiple pregnancies (carrying more than one foetus).
• Monitoring the overall health of the foetus and detecting potential issues like intestinal or heart defects.
• Providing a more accurate risk assessment for women over 35, those with a family history of birth defects, or those with pre-existing conditions such as diabetes.

Preparation For Quadruple Marker Test

Preparing for your quadruple marker test is simple and stress-free. While no strict guidelines are required, being informed can help you feel confident and prepared for the process.

Here are some helpful tips to make your quadruple marker test preparation smooth and stress-free:

• No fasting is required: You can eat or drink normally before the test.
• Wear comfortable clothing: This will make the blood sample collection easier and quicker.
• Inform your doctor: Share details of your medical history, ongoing medications, or previous test results.
• Know your dates: The test is recommended between 14 and 22.6 weeks of pregnancy, ideally with your latest ultrasound as required by the lab.
• Ask questions: It’s completely okay to ask your healthcare provider about the test, its purpose, and what to expect.

Remember, a calm and informed approach is a great start to your quadruple marker test preparation.

Procedure of the Quadruple Marker Test

The quadruple marker test procedure is simple, safe, and non-invasive. It is usually done during your second trimester and only requires a blood sample from you.

Here is how the quadruple marker test procedure usually goes:

• You will visit a clinic or opt for a home collection. Many labs offer the convenience of home visits by trained professionals.
• A small blood sample is taken from your arm using a sterile syringe.
• The sample is analysed in a lab to measure four specific markers: AFP, hCG, uE3, and Inhibin A.
• No physical discomfort or recovery time is needed: You can resume normal activities immediately.
• Reports are usually available within 24 hours, depending on the lab.

This easy and quick quadruple marker test procedure is designed to offer reassurance with minimal discomfort. If you’re nervous, don’t hesitate to speak to your care provider—they are there to support you.

Symptoms That May Call For Quadruple Marker Test

Not every pregnancy is the same, and sometimes your doctor may recommend the quadruple marker test based on certain symptoms or risk factors. This test helps assess the health of your baby, particularly regarding genetic and neural conditions.

Here are some reasons or symptoms that may prompt your doctor to recommend the test:

• You are over 35 years old at the time of pregnancy.
• There is a family history of genetic disorders or birth defects.
• Previous pregnancies had complications such as chromosomal abnormalities.
• You have diabetes or a chronic condition that may increase the risk of complications.
• Multiple pregnancies (e.g., twins or more).
• Elevated anxiety or concern about the baby’s development.

If any of these apply to you, don’t worry. This screening can provide peace of mind and important insights.

Quadruple Marker Test Interpretation

Once you have had the test, understanding your quadruple marker test result can help guide your next steps. Keep in mind—this is a screening test, not a diagnostic one.

Here is how to interpret it:

• Normal results mean your baby is at low risk for certain conditions.
• Abnormal results may indicate a higher risk for issues like Down syndrome or neural tube defects.
• Follow-up tests such as NIPT or amniocentesis may be recommended if risks are elevated.
• Always consult your doctor to explain your quadruple marker test result in context with your medical history.

Your healthcare provider will help you understand the quadruple marker test report in a calm and supportive way.

Factors That Can Affect the Quadruple Marker Test Result

There are several factors that can influence the accuracy or clarity of your quadruple marker test result. Knowing these can help you understand why follow-up testing might be necessary.

Some of the main factors include:

• Gestational age: The test is most accurate when done between 14 and 22.6 weeks. Incorrect dating can affect outcomes.
• Maternal weight: Higher body mass may dilute blood markers, influencing results.
• Multiple pregnancies: Carrying twins or more can alter marker levels.
• Existing health conditions: Diabetes or thyroid disorders may influence hormone levels.
• Lifestyle factors: Smoking or certain medications might skew results.
• Ethnicity: Some marker ranges differ slightly based on ethnicity, which labs may consider during interpretation.
• Incorrect sample handling or timing: Although rare, lab-related issues can affect the quadruple marker test result.

Understanding these influences helps you approach any abnormal results with clarity, not fear.

Conclusion

The Pregascreen Quadruple Marker Reflex Test offers expectant mothers valuable insight into their baby's health during the second trimester. With the right timing and proper quadruple marker test preparation, this screening is simple, safe, and supportive of early detection. 

For accurate results and compassionate care, Metropolis Healthcare stands out with its NABL-accredited labs, expert pathologists, and trusted diagnostic services across India.

Quadruple Marker Test Price in Different Cities

The quadruple marker test price can vary depending on your city and the diagnostic lab you choose. Most reputed labs offer transparent pricing and quick reports.

Here is a general idea of the price range in various Indian cities:

Please note that these are approximate figures and may vary depending on service quality, lab accreditation, and whether you opt for home collection. Always check with your local provider for the exact quadruple marker test price.

List of Parameters Considered During the Quad Marker Test

The Quadruple Test or Quadruple Marker Test measures the levels of four specific biochemical markers in the mother's blood:

• Alpha-fetoprotein (AFP): Produced by the foetus, abnormal levels may indicate neural tube defects, multiple pregnancies, or chromosomal abnormalities.
• Human Chorionic Gonadotropin (hCG) or free hCG: Produced by the placenta, higher levels are associated with an increased risk of Down syndrome.
• Inhibin A: Also produced by the placenta, elevated levels are linked to an increased risk of Down syndrome.
• Unconjugated Estriol (uE3): Produced by the foetus and placenta, lower levels may indicate an increased risk of Down syndrome or other chromosomal abnormalities.

Home Collection for Quad Marker Test Near You

Metropolis Healthcare is committed to providing expectant mothers with the utmost comfort, safety, and convenience when it comes to prenatal testing. Our home sample collection service for the Quadruple Marker Test allows you to complete this important screening from the safety and ease of your home. Our trained phlebotomists will arrive at your preferred time and place, ensuring precise sample collection and adherence to the highest standards.

With Metropolis Healthcare, you can expect prompt and reliable Quadruple Test results without compromising on quality. We are committed to making healthcare accessible and providing the best diagnostic solutions right at your doorstep, ensuring a seamless and stress-free experience for expectant mothers.