17p Deletion by FISH, p53 (MM, CLL)

Reasons for Undergoing the 17p Deletion by FISH Test

There are several key reasons why your doctor may recommend the FISH 17p Deletion test:

• Diagnosis and Prognosis: This FISH 17p Deletion test is crucial for assessing patients with CLL and other blood cancers. It helps predict the course of the disease and guides treatment choices.
• Treatment Resistance: Patients with a 17p deletion often resist standard chemotherapy. This test is vital for developing an effective treatment plan.
• Monitoring Disease Progression: The FISH 17p Deletion test can be done repeatedly during treatment to track the disease's progress and detect new chromosomal changes.

List of Parameters Considered During the 17p Deletion by FISH Test

The primary parameter measured in FISH 17p Deletion test is the presence or absence of the TP53 gene on chromosome 17p:

• Number of Signals: Normally, two signals are observed per cell, indicating the presence of two copies of the TP53 gene. If only one or no signal is observed, it indicates a deletion of the 17p region.
• Percentage of Affected Cells: The test quantifies the percentage of cells that have the 17p deletion. This percentage can vary widely among patients and is an important prognostic indicator. A higher percentage of cells with the deletion may indicate a poorer prognosis and greater resistance to standard therapies.

17p Deletion by FISH Test Preparation

To ensure accurate results, proper preparation for the FISH 17p Deletion test is essential:

• Specimen Collection: The FISH 17p Deletion test typically requires a bone marrow aspirate or whole blood sample. For bone marrow, 3 mL of aspirate is collected in a sodium heparin (green-top) tube. For blood, 10 mL (adults) or 3-5 mL (paediatric) is collected in a sodium heparin or EDTA (lavender-top) tube. Lithium heparin should be avoided.
• Storage and Transport: Specimens should be refrigerated and transported using a cold pack to maintain cell viability. The cold pack should not be in direct contact with the specimen.
• Avoiding Contamination: Ensure the specimen is not contaminated with cellular debris or stained slides, and avoid freezing or decalcifying the specimens.

17p Deletion by FISH Test Results & Interpretation

The results of the FISH 17p Deletion test indicate the presence and extent of the 17p deletion:

• Positive Result: If the FISH 17p Deletion test shows a significant percentage of cells with only one or no signal for the TP53 gene, it indicates the presence of a 17p deletion. This is associated with a poorer prognosis and potential resistance to standard chemotherapy.
• Negative Result: If two signals are observed in the majority of cells, it suggests that there is no significant deletion of the 17p region.
• Interpretation: The percentage of cells with the deletion is crucial for clinical decision-making. Higher percentages often correlate with more aggressive disease and the need for alternative or intensive treatment strategies.

Home Collection for 17p Deletion by FISH Test Near You

Metropolis Healthcare provides a home sample collection service for the FISH 17p Deletion test. A trained phlebotomist will visit your home to collect the necessary blood or bone marrow sample. This ensures your comfort and safety. Metropolis Healthcare upholds the highest standards in sample handling and testing accuracy. You can trust the reliability of your results.

With timely and detailed reports, you can make informed health decisions. Choosing Metropolis Healthcare for your FISH 17p Deletion test means partnering with a trusted name in diagnostics. They are committed to delivering quality healthcare that is accessible and convenient for everyone.