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3-Methyl Histidine Quantitative Serum Test
No special precautions
Sample Type
Blood
Recommended for
Male, Female
Report
Within 24 Hours
Blood test at Home
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3 Methyl Histidine Quantitative Serum Test Overview
3-Methyl histidine is a byproduct of skeletal muscle breakdown and is present in the blood in trace amounts. Its levels reflect the rate of skeletal muscle protein breakdown in the body.
The 3 Methyl Histidine Quantitative serum test is a specialised diagnostic tool that measures the levels of 3-Methyl Histidine (3-MH) in the blood. 3-MH is a modified amino acid produced during the breakdown of actin and myosin, the primary contractile proteins found in skeletal muscles.
By quantifying the concentration of 3-MH in the serum, this test provides valuable insights into the rate of muscle protein breakdown and turnover.
The 3 Methyl Histidine Quantitative serum test is particularly useful in assessing muscle catabolism in various physiological and pathological conditions. It can help evaluate muscle injury, monitor the effects of intense physical exercise or strength training, and assess muscle wasting in chronic diseases such as cancer, chronic heart failure, or muscular disorders.
Moreover, this test can be used to study the metabolic changes associated with prolonged bed rest, inactivity, fasting states, or specific dietary patterns.
Reasons for Undergoing the 3 Methyl Histidine Quantitative Serum Test
There are several reasons why a healthcare provider may recommend the 3 Methyl Histidine Quantitative serum test:
- To assess muscle protein breakdown, particularly in conditions involving muscle injury, intense physical exercise, or strength training
- To monitor muscle catabolism in chronic diseases such as cancer, chronic heart failure, or muscular disorders
- To evaluate the effects of prolonged bed rest or inactivity on muscle tissue
- To study the metabolic changes associated with fasting states or specific dietary patterns
List of Parameters Considered During the 3 Methyl Histidine Quantitative Serum Test
The primary parameter measured in the 3 Methyl Histidine Quantitative serum test is:
- Concentration of 3-MH: This indicates the rate of skeletal muscle protein breakdown. Elevated levels suggest increased muscle catabolism, which can be due to various physiological or pathological conditions such as muscle injury, intense exercise, or chronic diseases.
3-Methyl Histidine Quantitative Serum Test Preparation
Proper preparation is essential for accurate results in 3 Methyl Histidine Quantitative serum test. The following steps should be followed:
- Fasting: Patients are typically required to fast overnight for at least 4 hours to minimise the influence of recent dietary intake on the test results.
- Specimen Collection: Blood is collected in a green top (sodium heparin) tube. The specimen should be placed on wet ice immediately and centrifuged to separate the plasma within 4 hours if not done immediately. The plasma is then aliquoted into a plastic vial and frozen.
- Avoidance of Certain Tubes: Thrombin-activated tubes should not be used for collection.
3-Methyl Histidine Quantitative Serum Test Results & Interpretation
The results of the 3 Methyl Histidine Quantitative serum test are interpreted based on the concentration of 3-MH in the serum:
- Normal Levels: The average concentration of 3-MH in human blood plasma is approximately 2.85 micromolar (μM) with a range of 0.0–5.9 μM.
- Elevated Levels: Indicate increased muscle protein breakdown, which can be due to muscle injury, intense physical exercise, fasting states, or chronic diseases leading to muscle catabolism.
- Interpretation: Results need to be correlated with clinical context, including patient history, physical condition, and other diagnostic findings.
Home Collection for 3 Methyl Histidine Quantitative Serum Test
Metropolis Healthcare offers a convenient home collection service for 3-Methyl Histidine Quantitative serum test, ensuring a comfortable and safe experience for patients. A trained phlebotomist will visit your home to collect the blood sample, maintaining high standards of sample handling and testing accuracy.
This service allows you to receive timely and reliable results without compromising on the quality of diagnostic solutions. Metropolis Healthcare is committed to making healthcare accessible by providing expert diagnostic services conveniently at your doorstep.
3-Methyl Histidine Quantitative Serum Test Price
Metropolis Healthcare is a leading diagnostics centre and pathology lab in India equipped with the latest state-of-the-art technologies that provides the 3-Methyl Histidine Quantitative Serum Test with a clear pricing structure.
The 3-Methyl Histidine Quantitative Serum Test Price in Mumbai is ₹ 6,510 .
We are committed to deliver accurate and quality results from the best labs in India with complete transparency regarding test cost and turnaround time. No matter where you are, we strive to offer patients high-quality service that is affordable and accessible.
Frequently Asked Questions
This test measures the levels of 3-Methyl histidine in your blood.
This test is helpful in diagnosing muscular disorders and assessing their severity. It may be used to
- Diagnose muscle atrophy caused by disuse or diseases such as muscular dystrophy.
- Monitor the effectiveness of treatment for muscular disorders.
- Assess nutritional status and monitor protein intake.
Your doctor may recommend this test if you have
- Symptoms suggestive of muscle weakness, such as difficulty climbing stairs or lifting objects.
- A previous diagnosis of muscular dystrophy or other muscle disorders.
- A history of prolonged immobilisation.
- Nutritional deficiencies or malabsorption syndromes that affect protein metabolism.
Low levels of 3-Methyl histidine suggest decreased protein breakdown, while high levels can indicate muscle wasting due to disuse or disease.
For this test, a healthcare professional will draw a blood sample from your arm. The procedure is quick and relatively painless.
To prepare for this test:
- Fast for at least 8 hours before the test; only water is allowed.
- Inform your doctor of all medications and supplements you are taking before the test, as some drugs may interfere with the results.
- Please reach out to your healthcare provider for any specific requirements.
Other tests that may be ordered alongside this test include the following:
- Creatine kinase testing: This test measures the levels of an enzyme that indicates muscle damage or injury.
- Electromyography (EMG): This evaluates nerve and muscle function.
- Magnetic Resonance Imaging (MRI): This images the body to detect muscle abnormalities.
3MH test or 3-MH quantitative test
Muscular dystrophy is a group of disorders characterised by progressive muscle weakness and wasting due to a genetic mutation. Symptoms usually begin in childhood and worsen over time, leading to difficulty walking, standing, and performing daily activities.
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